2024年6月25日，默沙東宣布，其PD-1抑制劑帕博利珠單抗（商品名：可瑞達(dá)?）已獲得中國國家藥品監(jiān)督管理局（NMPA）批準(zhǔn)聯(lián)合曲妥珠單抗、含氟尿嘧啶類和鉑類藥物化療，用于經(jīng)充分驗(yàn)證的檢測評(píng)估腫瘤表達(dá)PD-L1（綜合陽性評(píng)分（CPS）≥1）的局部晚期不可切除或轉(zhuǎn)移性HER2陽性胃或胃食管結(jié)合部腺癌患者的一線治療。此次新適應(yīng)證的獲批是基于全球III期臨床試驗(yàn)KEYNOTE-811的數(shù)據(jù)。

根據(jù)WHO發(fā)布的最新數(shù)據(jù)，中國每年胃癌新增病例數(shù)約35.8萬例，死亡病例數(shù)約26萬例1。絕大多數(shù)的胃癌是腺癌，約占到95%以上2。中國胃癌患者早期占比很低，僅約20%，大多數(shù)患者發(fā)現(xiàn)時(shí)已是進(jìn)展期3，而晚期胃癌五年生存率不到10%4。

若您想了解更多有關(guān)疾病知識(shí)的信息，請(qǐng)咨詢醫(yī)療衛(wèi)生專業(yè)人士

文獻(xiàn)參考：
1.World Heath Organization, IARC, Globocan 2022. Cancer Today: China Fact Sheet
2.馬乾宸, 張本炎, 芮煒瑋, 王婷, 羅方秀, 王朝夫, 袁菲. 中國3 071例胃癌病理分型分析[J]. 診斷學(xué)理論與實(shí)踐, 2022, 21(05): 560-566.
3.中華人民共和國國家衛(wèi)生健康委員會(huì)醫(yī)政醫(yī)管局. (2022) 胃癌診療指南 http://www.nhc.gov.cn/yzygj/s7659/202204/a0e67177df1f439898683e1333957c74/files/dfc6063ce0a441a5b6d9c7350cac2c2a.pdf
4.Li H, Zhang H, Zhang H, Wang Y, Wang X, Hou H; Global Health Epidemiology Reference Group. Survival of gastric cancer in China from 2000 to 2022: A nationwide systematic review of hospital-based studies. J Glob Health. 2022 Dec 17;12:11014. doi: 10.7189/jogh.12.11014. PMID: 36527356; PMCID: PMC9759711.
5.中國抗癌協(xié)會(huì)胃癌專業(yè)委員會(huì), 中國抗癌協(xié)會(huì)腫瘤內(nèi)鏡學(xué)專業(yè)委員會(huì). 胃癌胃鏡活檢標(biāo)本HER-2檢測中國專家共識(shí)（2023版）[J]. 中國腫瘤臨床, 2023, 50(19): 973-982. doi: 10.12354/j.issn.1000-8179.2023.20230961
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8.Wang J, Sun N, Kunzke T, Shen J, Feuchtinger A, Wang Q, Meixner R, Gleut RL, Haffner I, Luber B, Lordick F, Walch A. Metabolic heterogeneity affects trastuzumab response and survival in HER2-positive advanced gastric cancer. Br J Cancer. 2024 Apr;130(6):1036-1045. doi: 10.1038/s41416-023-02559-6. Epub 2024 Jan 24. PMID: 38267634; PMCID: PMC10951255.
9.Kawakami T, Yamazaki K. Recent Progress in Treatment for HER2-Positive Advanced Gastric Cancer. Cancers (Basel). 2024 Apr 30;16(9):1747. doi: 10.3390/cancers16091747. PMID: 38730700; PMCID: PMC11083522.

來源：默沙東中國官微