論文標(biāo)題：Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model (膜性腎病和其他類(lèi)型腎病的比較分析和診斷模型的建立)

期刊：Frontiers of Medicine

作者：Hanyu Zhu（朱晗玉）, Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen（陳香美）, Dong Zhang

發(fā)表時(shí)間：09 Aug 2018

DOI：10.1007/s11684-018-0620-5

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中國(guó)人民解放軍總醫(yī)院腎臟病科朱晗玉和陳香美等在Frontiers of Medicine 發(fā)表研究論文《膜性腎病和其他類(lèi)型腎病的比較分析和診斷模型的建立》（Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model）。

膜性腎病是常見(jiàn)的慢性腎臟病之一，其診斷金標(biāo)準(zhǔn)為腎活檢穿刺，但因其有創(chuàng)、操作復(fù)雜而未廣泛普及。本研究通過(guò)Logistic回歸分析建立的無(wú)創(chuàng)診斷模型可有效診斷膜性腎病，且靈敏度和特異性較高，有廣泛的臨床應(yīng)用潛力。

摘 要 本研究比較了膜性腎病（MN）和非膜性腎?。╪on-MN）患者的臨床特征，建立了MN的無(wú)創(chuàng)診斷模型。納入MN患者248例和非MN患者550例，Logistic回歸分析顯示有三個(gè)因素（抗PLA2R抗體、IgG和肌酐）與MN獨(dú)立相關(guān)，然后將其用于建立MN診斷模型。ROC曲線證實(shí)我們的診斷模型可以有效對(duì)MN患者進(jìn)行診斷，其敏感性為79.9％，特異性為89.4％，曲線下面積為0.917。說(shuō)明此無(wú)創(chuàng)診斷模型可有效診斷MN，有廣泛的臨床應(yīng)用潛力。

摘要

This study aimed to compare clinical features between membranous nephropathy (MN) and nonmembranous nephropathy (non-MN), to explore the clinically differential diagnosis of these two types, and to establish a diagnostic model of MN. After renal biopsy was obtained, 798 patients were divided into two groups based on their examination results: primary MN group (n = 248) and non-MN group (n = 550). Their data were statistically analyzed. Logistic regression analysis indicated that anti-PLA2R antibodies, IgG, and Cr were independently correlated with MN, and these three parameters were then used to establish the MN diagnostic model. A receiver operating characteristic (ROC) curve confirmed that our diagnostic model could distinguish between patients with and without MN, and their corresponding sensitivity, specificity, and AUC were 79.9%, 89.4%, and 0.917, respectively. The cutoff value for this combination in MN diagnosis was 0.34. The established diagnostic model that combined multiple factors shows a potential for broad clinical applications in differentiating primary MN from other kidney diseases and provides reliable evidence supporting the feasibility of noninvasive diagnosis of kidney diseases.

原文信息

標(biāo)題

Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model

作者

Hanyu Zhu, Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen, Dong Zhang

機(jī)構(gòu)

1. Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing Key Laboratory of Kidney Disease, Beijing 100853, China

2. Department of Clinical Biochemistry, Chinese PLA General Hospital, Beijing 100853, China

3. Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

Corresponding Authors Yong Wang and Dong Zhang

Cite this article

Hanyu Zhu, Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen, Dong Zhang. Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model. Front. Med., 2019, 13(5): 618–625 https://doi.org/10.1007/s11684-018-0620-5

https://journal.hep.com.cn/fmd/EN/10.1007/s11684-018-0620-5

https://link.springer.com/article/10.1007/s11684-018-0620-5

來(lái)源：Frontiers of Medicine